esmfold2

Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the ESMC-{300M,600M,6B} protein language models from the same release: masked-LM logits, hidden states, mutation scoring, contact prediction, and the SAE interpretability head. MIT-licensed weights on HuggingFace org `biohub`. Use this skill when: (1) Predicting complex structures with single-sequence input, (2) Validating designed binders with ESMFold2-Fast, (3) Running ESMFold2 with MSA input, (4) Getting ESMC embeddings or per-residue mutation scores, (5) Choosing kernel backend and sampling-step settings for paper-faithful throughput.

请帮我安装这个 Agent Skill：https://github.com/aipoch/open-science/tree/main/resources/skills/esmfold2

1. 先读取该目录下的 SKILL.md 和其他文件，检查是否有可疑内容（执行未知脚本、读取密钥、向外发送数据等），用中文告诉我它会做什么、需要哪些权限；
2. 等我确认后，再把整个目录安装到 ~/.claude/skills/esmfold2/（如果你不是 Claude Code，安装到你自己约定的 skills 目录）；
3. 安装后告诉我怎么触发它。

git clone --depth 1 --filter=blob:none --sparse https://github.com/aipoch/open-science.git /tmp/esmfold2-src
cd /tmp/esmfold2-src && git sparse-checkout set "resources/skills/esmfold2"
mkdir -p ~/.claude/skills && cp -r "resources/skills/esmfold2" ~/.claude/skills/esmfold2

Skill 可以让智能体执行脚本。安装第三方 Skill 前务必看一遍内容，详见「安全」一课。