alphagenome

查找 AlphaGenome 基因变异影响

Looks up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18 SHAP feature attributions, plus raw and quantile scores for RNA-seq, DNase, ATAC, ChIP-TF, ChIP-histone, CAGE, PRO-cap, splicing, polyadenylation and contact-map tracks), scores variants or scans windows on demand with the AlphaGenome model for human and mouse (variant scoring, in silico mutagenesis, REF-versus-ALT track prediction), and builds Atlas website deep links. Use when the user mentions AlphaGenome, AlphaGenome Atlas, AVI or AlphaGenome Variant Impact, DeepMind variant effect prediction, or wants to prioritise or mechanistically interpret non-coding, regulatory, splicing, enhancer, promoter, or chromatin-accessibility effects of SNVs from a VCF, credible set, or region. Research use only; not a clinical tool.

请帮我安装这个 Agent Skill：https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/alphagenome

1. 先读取该目录下的 SKILL.md 和其他文件，检查是否有可疑内容（执行未知脚本、读取密钥、向外发送数据等），用中文告诉我它会做什么、需要哪些权限；
2. 等我确认后，再把整个目录安装到 ~/.claude/skills/alphagenome/（如果你不是 Claude Code，安装到你自己约定的 skills 目录）；
3. 安装后告诉我怎么触发它。

git clone --depth 1 --filter=blob:none --sparse https://github.com/K-Dense-AI/scientific-agent-skills.git /tmp/alphagenome-src
cd /tmp/alphagenome-src && git sparse-checkout set "skills/alphagenome"
mkdir -p ~/.claude/skills && cp -r "skills/alphagenome" ~/.claude/skills/alphagenome

Skill 可以让智能体执行脚本。安装第三方 Skill 前务必看一遍内容，详见「安全」一课。